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What is Meloxicam and how it works


Meloxicam (US trade name – Mobic) is the non-steroidal anti-inflammatory drug (NSAID). It is enolic acid derivative with anti-inflammatory, analgesic and antipyretic action. It is a preferential inhibitor of the inducible cyclooxygenase-2 (COX-2), responsible for the synthesis of pro-inflammatory prostaglandins. To a small extent inhibits constitutive cyclooxygenase-1 (COX-1), responsible for the synthesis of prostaglandins meet physiological functions. In the gastrointestinal tract is absorbed almost completely (90%). Plasma concentrations are in linear dependence on the dose. t1/2 in blood is 20 hours. In the synovial fluid concentration of 50% is achieved in the blood. In more than 99% bound to plasma proteins, primarily albumin. 95% metabolized in the liver – inactive metabolites are excreted in the urine of 50% and 50% in the faeces; 5% of the drug is excreted unchanged in the feces and trace amounts in the urine. Very slightly inhibits platelet aggregation, preferentially acts on COX-2.


Meloxicam is used for short-term symptomatic treatment of exacerbations of osteoarthritis and long-term symptomatic treatment of rheumatoid arthritis and ankylosing spondylitis.

Side Effects

Like all medicines, Meloxicam can cause side effects, although they do not occur in all patients using this preparation. Remember that the expected benefits of the drug are usually larger than the damage resulting from the emergence of side effects.

Drug Interaction

Meloxicam used simultaneously with other NSAIDs and/or corticosteroids increases the risk of gastrointestinal bleeding. Dehydrated patients concomitant use of diuretics increases the risk of renal failure. This may increase the toxicity of methotrexate (blood counts should be monitored), and increases the effect of cyclosporine nephrotoxicity. More…


Do not use any medication without consulting your doctor during pregnancy! It is very important that before taking any medicine during pregnancy or breast-feeding consult with your doctor and explain beyond doubt the potential risks and benefits associated with the use of the drug. If you are pregnant or plan to become pregnant, inform your doctor prescribing a this drug (see warnings in section “Take special care with preparation?”). Use of the product is contraindicated in pregnant women. Should not be used in women who are breastfeeding. More…


There are no studies on the effects on ability to drive and use machines / equipment. However, the preparation may cause side effects such as blurred vision, drowsiness, dizziness, fatigue, or other central nervous system disorders, and if they occur, do not drive or operate machinery / equipment and perform other activities that require intense concentration. Some diseases and other circumstances may contraindicate the use or indication for dosage adjustment. In some situations it may be necessary to carry out specific examinations. The use of the lowest effective dose for the shortest possible period reduces the risk of side effects. Avoid parallel use of other nonsteroidal anti-inflammatory drugs (including selective COX-2 inhibitors). More…

Dosing and Administration

meloxicam tablet

The drug is for oral use only. Meloxicam is available in the form of 7.5 mg or 15 mg tablets. The tablets should be taken with a meal and liquid. The dose and frequency of drug administration should be determined by your doctor. Do not use concomitantly with other non-steroidal anti-inflammatory drugs (NSAIDs) such as naproxen. During treatment, avoid drinking alcoholic beverages. More…