The most common side effects of meloxicam affect gastrointestinal tract: nausea, vomiting, dyspepsia, abdominal pain, bloating, diarrhea, constipation, gastritis, inflammation of the lining of the mouth or esophagus, gastrointestinal bleeding (including tarry stools, bloody vomiting) and gastrointestinal ulceration sometimes with bleeding and perforation (including fatal, especially in elderly patients), inflammation of the lining of the colon, exacerbation of colitis, exacerbation of Crohn’s disease, increased liver enzymes, rarely hepatitis, liver failure, jaundice, pancreatitis.
Possible: headache, dizziness, fatigue, drowsiness, mood disorders, insomnia, nightmares, confusion, nervousness, depression, anxiety, visual disturbances (including blurred vision), conjunctivitis, tinnitus. Possible heart failure, palpitations, coronary heart disease (angina pectoris), edema, hypertension, vasculitis, flushing, fainting, hematologic disorders, including anemia, agranulocytosis, leukopenia, thrombocytopenia (if you develop symptoms such as fever, sore throat, flu-like symptoms, superficial ulceration of the mouth, fatigue, epistaxis, bruising, petechiae or purpura should immediately consult a doctor, as this may be the first signs of haematological disorders).
Possible impairment of renal function, sodium and water retention, renal failure, increased blood urea and creatinine in the blood. Hypersensitivity reactions (rash, hives, itching, sensitivity to light) and anaphylactic reactions, including forming life-threatening anaphylactic shock, angioedema (swelling of the face, larynx, tongue, and throat that may cause difficulty breathing), bronchospasm, asthma attack and severe skin reactions: toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme. Long-term use of meloxicam in high doses may increase the risk of heart attack or stroke.